The year is 1938. James Lee Quatermain is a man of many talents, yet holding on to money isn't one of them. Quatermain isn't all too keen on escorting Jennifer Goodwin, a US agent and former colleague of his, to an Egyptian temple complex in order to retrieve an ancient artifact - The Heart of Atlantis. Neither does he believe in the reputed invigorating qualities of this artifact, nor does he care that a division of the Ahnenerbe, the Nazi department specialized in the occult, is after The Heart as well. But life has its ways of changing one's perspective. Quatermain soon finds himself part of a hunt across the globe - from the stormy deserts of Egypt to the icy depths of the Arctic and all the way to the steaming jungles of Guatemala.