The story of Prey 2 focuses on U.S. Marshall Killian Samuels, who starts the game on a passenger flight which suddenly crashes onto the Sphere (the crash is shown in the original Prey). After a short battle with some aliens, he is knocked uncounscious after which the plot jumps forward several years. Samuels is now a bounty hunter on the alien world Exodus. Though he is aware of his profession and has retained his skills, he has no memory of what happened in the time that passed since his abduction. He initially believes himself to be the only human on Exodus until he runs into Domasi "Tommy" Tawodi, whom he has apparently met in the period he no longer remembers. Killian then resumes his bounty hunter activities while recovering his memory.