The Lost and Damned takes place in Liberty City at the same time as Niko's tale from GTA IV. You play as Johnny "The Jew" Klebitz, Vice President of the biker gang named The Lost. Johnny's been the de facto leader while the President of The Lost, Billy, has been in rehab. The story begins with Billy's release and resumption of duties as head of the gang. This naturally leads to a conflict as Billy looks to dive nose-first into the drug trade while Johnny wants The Lost to be smarter about how it handles its business.